最近の成果

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学術論文

2021

Visualizing intra-medulla lipids in human hair using ultra-multiplex CARS, SHG, and THG microscopy,
Daiki Kaneta,Makiko Goto, Motofumi Hagihara, Philippe Leproux, Vincent Couderc, Mariko Egawa, and Hideaki Kano,
Analyst 146(4), 1163-1168 (2021), DOI: 10.1039/d0an01880e.

Terahertz scanning tunneling microscopy for visualizing ultrafast electron motion in nanoscale potential variations,
S. Yoshida, Y. Arashida, H. Hirori, T. Tachizaki, A. Taninaka, H. Ueno, O. Takeuchi, and H. Shigekawa,
ACS Photonics 8, 315-323 (2021), DOI:10.1021/acsphotonics. 0c01572.

2020

The effect of ion irradiation on dephasing of coherent optical phonons in GaP,
T. Ichikawa, Y. Saito, and M. Hase,
AIP Advances 10, 105117 (2020), DOI: 10.1063/5.0020810.

High-quality sputter-grown layered chalcogenide and pnictide films for phase change memory applications and beyond,
Y. Saito, P. Fons, A. V. Kolobov, K. V. Mitrofanov, K. Makino, J. Tominaga, S. Hatayama,
Y. Sutou, M. Hase, and J. Robertson,
Journal of Physics D: Applied Physics, 53, 284002 (2020).

Ultrafast dynamics of the low frequency shear phonon in 1T'-MoTe2,
T. Fukuda, K. Makino, Y. Saito, P. Fons, A. V. Kolobov, K. Ueno, and M. Hase,
Appl. Phys. Lett. 116, 093103 (2020).

Contrast-tuneable microscopy for single-shot real-time imaging,
I. Shimizu, Y. Saikawa, K. Uno, H. Kano and S. Shimizu,
The European Physical Journal Applied Physics 91, 30701 (2020),
DOI:https://doi.org/10.1051/epjap/2020200101.

Nanoscale phase change on Ge2Sb2Te5 thin films induced by optical near fields with photoassisted scanning tunneling microscope,
K. Asakawa, Dang-il Kim, S. Yaguchi, M. Tsujii, K. Yoshioka, Y. Arashida, S. Yoshida, H. Shigekawa, M. Kuwahara, I. Katayama and J. Takeda,
Appl. Phys. Lett. 117, 211102 (2020),DOI:10.1063/5.0032573.

Measuring viscoelasticity of soft biological samples using atomic force microscopy,
Y. M. Efremov, T. Okajima, A. Raman,
Soft Matter 16, 64-81(2020).

Relationship between rheological properties and actin filaments of single cells investigated by atomic force microscopy,
R. Tanaka, M. Sawano, Y. Fujii, K. Kuribayashi-Shigetomi, A. Subagyo, K. Sueoka, T. Okajima,
Japanese Journal of Applied Physics 59, SN1010 (2020) ,DOI:10.35848/1347-4065/ab8e23.

Multimodal nonlinear optical imaging of caenorhabditis elegans with multiplex coherent anti-stokes Raman scattering (CARS), third harmonic generation (THG), second harmonic generation (SHG), and two-photon excitation fluorescence (TPEF),
S. Miyazaki, P. Leproux, V. Couderc, Y. Hayashi and H. Kano,
Applied Physics Express 13, 7 (2020), DOI: 10.35848/1882-0786/ab9711.

Photo-induced meta-stable polar conformations in polystyrene microspheres revealed by time-resolved SHG microscopy,
K. Makihara, D. Kaneta, T. Iwamura, A. Sugita, P. Leproux, V. Couderc, and H. Kano,
Applied Physics Express 13, 052003 (2020), DOI:10.35848/1882-0786/ab84be.

2019

Subcycle mid-infrared coherent transients at 4 MHz repetition rate applicable to light-wave-driven scanning tunneling microscopy,
K. Yoshioka, I. Igarashi, S. Yoshida, Y. Arashida, I. Katayama, J. Takeda, and H. Shigekawa,
Optics Letters 44, 21, 5350-5353 (2019), DOI: 10.1364/OL.44.005350.

Giant nonlinear optical effects induced by nitrogen-vacancy centers in diamond crystals,
M. Motojima, T. Suzuki, H. Shigekawa, Y. Kainuma, T. An, and M. Hase,
Optics Express 27, 22, 32217-32227 (2019), DOI: 10.1364/OE.27.032217.

New delay-time modulation scheme for optical pump-probe scanning tunneling microscopy (OPP-STM) with minimized light-intensity modulation,
O. Takeuchi, H. Mogi, Zi-han Wang, A. Taninaka, S. Yoshida, and H. Shigekawa,
Japanese Journal of Applied Physics 58, SIIA12 (2019), DOI: 10.7567/1347-4065/ab1255.

Antioxidant Effect of Hydrogen Nanobubble Contributes to Suppression of Tumor Cell Growth,
H. Kurokawa, H. Matsui, H. Ito, A. Taninaka, H. Shigekawa, G. Dodbiba, Y. Wei and T. Fujita,
Biomedical Journal of Scientific & Technical Research (BJSTR) 19, 5, 14592 (2019), DOI: 10.26717/BJSTR.2019.19.003361.

Photon energy dependence of Kerr rotation in GeTe/Sb2Te3 chalcogenide superlattices,
T. Suzuki, R. Mondal, Y. Saito, P. Fons, A. V. Kolobov, J. Tominaga, H. Shigekawa, and M. Hase,
Journal of Physics: Condensed Matter 31, 415502 (2019), DOI: 10.1088/1361-648X/ab2e9f.

The Atomic and Electronic Structure of 0° and 60° Grain Boundaries in MoS2,
T. Nakanishi, T. Taniguchi, K. Watanabe, S. Yoshida, K. Murase, O. Takeuchi, H. Shigekawa, H. Shinohara, and R. Kitaura,
Frontier Physics Volume 7, Article 59, (2019), DOI: 10.3389/fphy.2019.00059.

Nitric oxide regulates the expression of heme carrier protein-1 via hypoxia inducible factor-1α stabilization,
H. Kurokawa, H. Ito, M. Terasaki, D. Matano, A. Taninaka, H. Shigekawa and H. Matsui,
Plos One 14, e0222074 (2019).

Hydantoin and Its Derivatives Reduce the Viscosity of Concentrated Antibody Formulations by Inhibiting Associations via Hydrophobic Amino Acid Residues,
S. Nishinami, T. Kameda, T. Arakawa, and K. Shiraki,
Ind. Eng. Chem. Res, 58, 36, 16296-16306 (2019).

Optical Fingerprints of Proteases and Their Inhibited Complexes Provided by Differential Cross-Reactivity of Fluorophore-Labeled Single-Stranded DNA,
S. Tomita, H. Sugai, M. Mimura, S. Ishihara, K. Shiraki, R. Kurita,
ACS Appl Mater Interfaces, 11(50):47428–47436 (2019).

Selective separation method of aggregates from IgG solution by aqueous two-phase system,
C. Shibata, K. Iwashita, K. Shiraki,
Protein Expr Purif. 161, 57-62 (2019).

Binding affinity of uncharged aromatic solutes for negatively charged resins is enhanced by cations through cation–pai interaction: the case of sodium ion and arginine,
A. Hirano, K. Iwashita, T. Ura, S. Sakuraba, K. Shiraki, T. Arakawa, T. Kameda,
J. Chromato. A, 1595 97–107 (2019).

Effect of additives on liquid droplet of protein–polyelectrolyte complex for high-concentration formulations,
M. Mimura, K. Tsumura, A. Matsuda, N. Akatsuka, and K. Shiraki,
J Chem Phys. 150, 064903 (2019).

Effect of electrolyte ions on stability of flavin adenine dinucleotide-dependent glucose dehydrogenase,
M. Nemoto, K. Sugihara, T. Adachi, K. Murata, K. Shiraki, and S. Tsujimura,
ChemElectroChem, 6, 1028-1031(2019).

Array-based generation of response fingerprints with common fluorescent dyes for identification of proteins and cells,
M. Mimura, S. Tomita, R. Kurita, and K. Shiraki,
Anal Sci. 35, 99-102 (2019).

Non-chromatographic purification of teriparatide with a pH-responsive CspB tag,
T. Nonaka, N. Tsurui, T. Mannem, Y. Kikuchi, K. Shiraki,
Protein Expr. Purif. 155, 66-71 (2019).

Two Elution Mechanisms of MEP Chromatography,
T. Arakawa, M. Tokunaga, T. Maruyama, K. Shiraki,
Curr Protein Pept Sci. 20, 28-33 (2019).

Effects of Arginine on Multimodal Chromatography: Experiments and Simulations,
A. Hirano, K. Shiraki, and T. Kameda,
Curr Protein Pept Sci. 20, 40-48 (2019).

Rapid and scalable fabrication of reduced graphene oxide conducting films by ethanol-assisted thermal annealing of graphene oxide,
K. K. H. De Silva, H. Huang, S. Suzuki, M. Yoshimura,
Jpn. J. Appl. Phys. 58 (2019) SIIB07.

Growth of vertically-aligned carbon nanotubes on graphite for electric double-layer capacitors,
D. Yoneda, S. Suzuki, S. Hiramoto, Y. Matsuoka, M. Hara, M. Yoshimura,
Mat. Res. Express 6 (2019) 086322.

Oligomers imaging of amyloid-β 1-42 by scanning tunneling microscopy,
N. Naruse, H. Satooka, K. Todo, A. Nakanishi, H. Taguchi and Y. Mera,
Japanese Journal of Applied Physics 58(SIIB) 30-1-30-7 (2019).

High thermoelectric performance in high crystallinity epitaxial Si films containing silicide nanodots with low thermal conductivity,
S. Sakane, T. Ishibe, T. Hinakawa, N. Naruse, Y. Mera, Md. Mahfuz Alam, Kentarou Sawano, and Yoshiaki Nakamura,
Appl. Phys. Lett. 115, 182104(2019).

Thermoelectric power factor enhancement based on carrier transport physics in ultimately phonon-controlled Si nanostructures,
S. Sakane, T. Ishibe, T. Taniguchi, N. Naruse, Y. Mera, T. Fujita, Md. M. Alam, K. Sawano, N. Mori, Y. Nakamura,
Materialstoday Energy, 13, 56-63 (2019).

57Fe conversion electron Mössbauer study on tin oxide films doped with dilute two metal ions,
A. Nakanishi, K. Nomura, Y. Mera, Y. Koike,
Hyperfine Interaction, 240(1) (2019) DOI: 10.1007/s10751-019-1666-8.

Hyperthermia enhances photodynamic therapy by regulation of HCP1 and ABCG2 expressions via high level ROS generation,
H. Kurokawa, H. Ito, M. Terasaki, H. Matsui,
Sci Rep 9,1638, 2019.

Externally triggerable optical pump-probe scanning tunneling microscopy,
H. Mogi, Zi-han Wang, R. Kikuchi, Cheul-hyun Yoon, S. Yoshida, O. Takeuchi, and H. Shigekawa,
Appl. Phys. Express 12, 025005 (2019).

Enhancement of PDT-cytotoxicity via ROS induced by indomethacin in metastatic breast cancer,
A. Terasaki, H. Kurokawa, H. P. Indo, H. Bando, H. Hara, H. J. Majima, H. Matsui and H.Ito,
J Porphyr Phthalocyanine 23, 1440-1447 (2019).

Multiplex coherent anti-Stokes Raman scattering highlights state of chromatin condensation in CH region,
T. Guerenne-Del Ben, Z. Rajaofara, V. Couderc, V. Sol, H. Kano, P. Leproux and J. –M. Petit,
Scientific Reports 9, 13862 (2019).

Ultra-multiplex CARS spectroscopic imaging with 1-millisecond pixel dwell time,
H. Kano, T. Maruyama, J. Kano, Y. Oka, D. Kaneta, T. Guerenne, P. Leproux, V. Couderc, and M. Noguchi,
OSA Continuum 2(5), 1693-1705 (2019).

Characterization of Intra/Extra-Cellular Water States Probed by Ultrabroadband Multiplex Coherent Anti-Stokes Raman Scattering (CARS) Spectroscopic Imaging,
M. Nuriya, H. Yoneyama, K. Takahashi, P. Leproux, V. Couderc, M. Yasui, and H. Kano,
Journal of Physical Chemistry A 123 , 3928-3934 (2019).

Ultimate High Conductivity of Multilayer Graphene Examined by Multiprobe Scanning Tunneling Potentiometry on Artificially Grown High-Quality Graphite Thin Film,
Hiroyuki Mogi, Takafumi Bamba, Mutsuaki Murakami, Yuki Kawashima, Masamichi Yoshimura, Atsushi Taninaka, Shoji Yoshida, Osamu Takeuchi, and Hidemi Shigekawa,
ACS Applied Electronic Materials 2019, 1, 1762-1771 (2019).

Continuous heteroepitaxy of two-dimensional heterostructures based on layered chalcogenides,
Yu Kobayashi, Shoji Yoshida, Mina Maruyama, Hiroyui Mogi, Kota Murase, Yutaka Maniwa, Osamu Takeuchi, Susumu Okada, Hidemi Shigekawa, Yasumitsu Miyata,
ACS Nano, (2019), DOI: 10.1021/acsnano.8b07991.

Sub-cycle transient scanning tunneling spectroscopy with visualization of enhanced terahertz near-field,
Shoji Yoshida, Hideki Hirori, Takehiro Tachizaki, Katsumasa Yoshioka, Yusuke Arashida,Zi-Han Wang, Yasuyuki Sanari, Osamu Takeuchi, Yoshihiko Kanemitsu, and Hidemi Shigekawa,
ACS Photonics, 6, 1356-1364(2019).

Development of laser-combined scanning multiprobe spectroscopy and application to analysis of WSe2/MoSe2 in-plane heterostructure,
Hiroyuki Mogi, Zi-Han Wang, Takafumi Banba, Yuhei Takaguchi, Naohiko Endo, Shoji Yoshida, Atsushi Taninaka, Haruhiro Oigawa, Yasumitsu Miyata, Osamu Takeuchi, and Hidemi Shigekawa,
Appl. Phys. Express 12, 045002 (2019).

Surface-mediated effect on electron spin dynamics probed by optical-pump-probe scanning tunneling microscopy,
Zi-han Wang, Cheul-hyun Yoon, Shoji Yoshida, Yusuke Arashida, Osamu Takeuchi, Yuzo Ohno and Hidemi Shigekawa,
Physical Chemistry Chemical Physics, 21,7256 (2019).

Co-aggregation of ovotransferrin and lysozyme,
Kazuki Iwashita, Akihiro Handa, Kentaro Shiraki,
Food Hydrocolloids, 89, 416-424 (2019).

Salt-containing aqueous two-phase system shows predictable partition of proteins with surface amino acids residues,
Chika Shibata, Kazuki Iwashita, Kentaro Shiraki,
Int. J. Biol. Macromol., 133, 1182-1186 (2019).

2018

Probing spin dynamics by time-resolved STM,
S. Yoshida, O. Takeuchi, H. Oigawa, and H. Shigekawa,
Solid State Physics 53, 4, 165 (2018).

Coacervates and coaggregates: Liquid-liquid and liquid-solid phase transitions by native and unfolded protein complexes,
K. Iwashita, A. Handa, K. Shiraki,
Int. J. Biol. Macromol. 120, 10-18 (2018).

Hyperactivation of serine protease by the Hofmeister effect,
A. Endo, T. Kurinomaru, and K. Shiraki,
Molecular Catalysis, 455, 32-37 (2018).

Effects of allantoin and dimethyl sulfoxide on the thermal aggregation of lysozyme,
S. Nishinami, A. Hirano, T. Arakawa, and K. Shiraki,
Int. J. Biol. Macromol., 119, 180-185 (2018).

Arginine suppresses opalescence and liquid–liquid phase separation in IgG solutions.
S. Oki, S. Nishinami, K. Shiraki,
Int. J. Biol. Macromol. 118, 1708-1712 (2018).

Viscosity Control of Protein Solution by Small Solutes: A Review,
T. Hong, K. Iwashita, K. Shiraki,
Current Protein and Peptide Science 19, 746-758 (2018).

Allantoin and hydantoin as new protein aggregation suppressors,
S. Nishinami, S. Yoshizawa, T. Arakawa and K. Shiraki,
Int. J. Biol. Macromol., 114, 497-503 (2018).

Salt-dependent Elution of Uncharged Aromatic Solutes in Ion-exchange Chromatography,
A. Hirano, K. Iwashita, S. Sakuraba, K. Shiraki, T. Arakawa, T. Kameda,
Journal of Chromatography A, 1546, 46-55 (2018).

A new pH-responsive peptide tag for protein purification,
T. Nonaka, N. Tsurui, T. Mannem, Y. Kikuchi, K. Shiraki,
Protein Expression and Purification 146, 91-96 (2018).

Specific solubilization of aromatic impurities in culture media: Arg solution improves purification of pH-responsive tag CspB50 with Teriparatide,
S. Oki, T. Nonaka, K. Shiraki,
Protein Expression and Purification 146, 85-90 (2018).

Mechanism of co-aggregation in a protein mixture with small additives,
S. Oki, K. Iwashita, M. Kimura, H. Kano, K. Shiraki,
Int. J. Biol. Macromol., 107, 1428-1437 (2018).

TMAO is a counteracting solute of benzyl alcohol for multi-dose formulation of immunoglobulin,
S. Yoshizawa, S. Oki, T. Arakawa, and K. Shiraki,
Int. J. Biol. Macromol., 107, 984-989 (2018).

CARS molecular fingerprinting using sub-100-ps microchip laser source with fiber amplifier,
H. Yoneyama, K. Sudo, P. Leproux, V. Couderc, A. Inoko, and H. Kano,
APL Photonics 3, 092408 (2018) DOI:10.1063/1.5027006.

Ultrabroadband Multiplex Coherent anti-Stokes Raman Scattering (CARS) Microspectroscopy Using a CCD Camera with an InGaAs Image Intensifier,
R. Fujisawa, T. Iwamura, P. Leproux, V. Couderc, H. Okada, and H. Kano,
Chemistry Letters 47(6), 704-707 (2018) DOI:10.1246/cl.180017.

Development of a Hyper-Raman Microspectroscopic System Using a Wavelength-tunable Laser Source,
Y. Yamada , N. Fukutake, K. Hiramatsu, and H. Kano,
Chemistry Letters 47(5), 660-663 (2018) DOI:10.1246/cl.180077.

Mechanism of co-aggregation in a protein mixture with small additives,
S. Oki, K. Iwashita, M. Kimura, H. Kano, and K. Shiraki,
Journal of Biological Macromolecules107, PartB,1428-1437 (2018) DOI:10.1016/j.ijbiomac.2017.10.004.

Suppression of the Single-Wall Carbon Nanotube Redox Reaction by Adsorbed Proteins,
T. Nakayama, T. Tanaka, K. Shiraki, M. Hase, and A. Hirano,
Appl. Phys. Exp. 11, 075101 (2018).

All-optical detection of periodic structure of chalcogenide superlattice using coherent folded acoustic phonons,
T. Suzuki, Y. Saito, P. Fons, A. V. Kolobov, J. Tominaga, and M. Hase,
Physica Status Solidi (RRL) - Rapid Research Letters, 12, 1800246 (2018).

Evidence for Ferromagnetic Clusters in the Colossal-Magnetoresistance Material EuB6,
M. Pohlit, S. Roessler, Y. Ohno, H. Ohno, S. von Molnar, Z. Fisk, J. Mueller, S. Wirth,
Phys. Rev. Lett. 120, 257201 (2018).

Liquid Droplet of Protein–Polyelectrolyte Complex for High-Concentration Formulations,
Ayumi Matsuda, Masahiro Mimura, Takuya Maruyama, Takaaki Kurinomaru, Shiuhei Mieda, and Kentaro Shiraki,
J. Pharm. Sci., 107, 2713-2719 (2018).

Laser-combined Scanning Tunneling Microscopy and Its Applications,
Hidemi Shigekawa, and Shoji Yoshida,
Association of Asia Pacific Physical Societies 28, 4, 9-18 (2018).

A cascading nonlinear magneto-optical effect in topological insulators,
R. Mondal, Y. Saito, Y. Aihara, P. Fons, A. V. Kolobov, J. Tominaga, S. Murakami, and M. Hase,
Scientific Reports, 8, 3908 (2018). (Selected as Top 100 in Physics )

A topological phase buried in a chalcogenide superlattice monitored by a helicity dependent Kerr measurement,
R. Mondal, Y. Saito, Y. Aihara, P. Fons, A. V. Kolobov, J. Tominaga, and M. Hase,
ACS Applied Materials & Interfaces, 10, 26781-26786 (2018).

Zener Tunneling Breakdown in Phase-Change Materials Revealed by Intense Terahertz Pulses,
Y. Sanari, T. Tachizaki, Y. Saito, K. Makino, P. Fons, A. V. Kolobov, J. Tominaga, K. Tanaka, Y. Kanemitsu, M. Hase, and H. Hirori,
Phys. Rev. Lett., 121, 165702 (2018).

The effect of nitrogen lone-pair interaction on the conduction in a single-molecule junction with amine-Au bonding,
Y. Sugita, A. Taninaka, S. Yoshida, O. Takeuchi, and H. Shigekawa
Scientific Reports, (2018).

2017

Noncovalent PEGylation through Protein-Polyelectrolyte Interaction: Kinetic Experiment and Molecular Dynamics Simulation,
T. Kurinomaru, K. Kuwada, S. Tomita, T. Kameda and K. Shiraki,
J. Phys. Chem. B. 121, 6785-6791 (2017).

One-step identification of antibody degradation pathways using fluo-rescence signatures generated by cross-reactive DNA-based arrays,
S. Tomita, A. Matsuda, S. Nishinami, R. Kurita, and K. Shiraki,
Anal. Chem. 89, 7818-7822 (2017).

SHG-specificity of cellular Rootletin filaments enables naïve imaging with universal conservation,
T. Akiyama, A. Inoko, Y. Kaji, S. Yonemura, K. Kakiguchi, H. Segawa, K. Ishitsuka, M. Yoshida, O. Numata, P. Leproux, V. Couderc, T. Oshika, and H. Kano,
Scientific Reports 7, 39967 (2017).

Allosteric Control of Nanomechanical DNA Origami Pinching Devices for Enhanced Target Binding,
A. Kuzuya, Y. Sakai, T. Yamazaki, Y. Xu, Y. Yamanaka, Y. Ohya, and M. Komiyama,
Chem. Commun., 53, 8276-8279 (2017).

Highly Efficient Preparation of Single-Stranded DNA Rings by T4 Ligase at Abnormally Low Mg(II) Concentration,
R. An, Q. Li, J. Li, M. Komiyama, and X. Liang,
Nucl. Acids Res., 45, e139 (2017).

Radiotherapy for cancer using X-ray fluorescence emitted from iodine,
M. Tamura, H. Ito, and H. Matsui,
Scientific Reports, 7, 43667(2017).

Modulation of the Local Density of States of Carbon Nanotubes by Encapsulation of Europium Nanowires As Observed by STM/STS,
T. Nakanishi, R. Kitaura, T. Kawai, S. Okada, S. Yoshida, O. Takeuchi, H. Shigekawa, and H. Shinohara,
The Journal of Physical Chemistry C, 121, 18195-18201 (2017).

2016

Sub-nanometre resolution of atomic motion during electronic excitation in phase-change materials,
K. Mitrofanov, P. Fons, K. Makino, R. Terashima, T. Shimada, A. V. Kolobov, J. Tominaga, V. Bragaglia, A. Giussani, R. Calarco, H. Riechert, T. Sato, T. Katayama, K. Ogawa, T. Togashi, M. Yabashi, S. Wall, D. Brewe, and M. Hase,
Scientific Reports, 6, 20633 (2016).

Anisotropic lattice response induced by a linearly-polarized femtosecond optical pulse excitation in interfacial phase change memory material,
K. Makino, Y. Saito, P. Fons, A. V. Kolobov, T. Nakano, J. Tominaga, and M. Hase,
Scientific Reports, 6, 19758 (2016).

Revealing conformational dynamics in single-molecule junction by site- and angle-resolved dynamic probe method,
S. Yoshida, A. Taninaka, Y. Sugita, T. Katayama, O. Takeuchi, and H. Shigekawa,
ACS Nano 10, 11211-11218 (2016).

Real-space coherent manipulation of electrons in a single tunnel junction by single-cycle terahertz electric fields,
K. Yoshioka, I. Katayama, Y. Minami, M. Kitajima, S. Yoshida, H. Shigekawa, and J. Takeda,
Nature Photonics 10, 762-765 (2016).

Modulation of electrical potential and conductivity in an atomic-layer semiconductor heterojunction,
Y. Kobayashi, S. Yoshida, R. Sakurada, K. Takashima, T. Yamamoto, T. Saito, T. Taniguchi, K. Watanabe, Y. Maniwa, O. Takeuchi, H. Shigekawa, and Y. Miata,
Scientific Reports 6, 31223 (2016).

Small amine molecules: Solvent design toward facile improvement of protein stability against aggregation and inactivation,
K. Shiraki, S. Tomita, and N. Inoue,
Curr. Pharm. Biotechnol., 17, 116-125 (2016).

Coherent anti-Stokes Raman scattering under electric field stimulation,
E. Capitaine, N. O. Moussa, C. Louot, C. Lefort, D. Pagnoux, J.-R. Duclère, J. F. Kaneyasu, H. Kano, Ludovic Duponchel, Vincent Couderc, and Philippe Leproux,
Physical Review B 94, 245136 (2016).

2015

Femtosecond structural transformation of phase-change materials far from equilibrium monitored by coherent phonons,
M. Hase, P. Fons, K. V. Mitrofanov, A. V. Kolobov, and J. Tominaga,
Nature Communications, 6, 8367 (2015).

Microscopic basis for the band engineering of Mo1-xWxS2-based heterojunction
S. Yoshida, Y. Kobayashi, R. Sakurada, S. Mori, Y. Miyata, H. Mogi, T. Koyama, O. Takeuchi, and H. Shigekawa,
Scientific Reports, 5. 14808 (2015).

Mechanically activated switching of Si-based single-molecule junction as imaged with three-dimensional dynamic probe
M. Nakamura, S. Yoshida, T. Katayama, A. Taninaka, Y. Mera, S. Okada, O. Takeuchi, and H. Shigekawa,
Nature Communications, 6, 8465 (2015).

Liquid chromatographic analysis of the interaction between amino acids and aromatic surfaces using single-wall carbon nanotubes,
K. Iwashita, K. Shiraki, R. Ishii, T. Tanaka, and A. Hirano,
Langmuir 31, 8923-8929 (2015).

2014

Spectroscopy: Nanoscale terahertz spectroscopy
H. Shigekawa, S. Yoshida, and O. Takeuchi,
Nature Photonics, News & Views 8, 815-817 (2014).

Probing ultrafast spin dynamics with optical pump-probe scanning tunnelling microscopy
S. Yoshida, Y. Aizawa, Z.n Wang, R. Oshima, Y. Mera, E. Matsuyama, H. Oigawa, O. Takeuchi, and H. Shigekawa,
Nature Nanotechnology 9, 588-593 (2014)

Specific decrease in solution viscosity of antibodies by arginine for therapeutic formulations,
N. Inoue, E. Takai, T. Arakawa, and K. Shiraki,
Mol. Pharm 11, 1889-1896 (2014).

Enzyme hyperactivation system based on generated reaction field by polyelectrolyte,
T. Kurinomaru, S. Tomita, Y. Hagihara, and K. Shiraki,
Langmuir 30, 3826-3831 (2014).

Surfactant Uptake Dynamics in Mammalian Cells Elucidated with Quantitative Coherent Anti-Stokes Raman Scattering Microspectroscopy,
M. Okuno, H. Kano, K. Fujii, K. Bito, S. Naito, P. Leproux, V. Couderc, and H. Hamaguchi,
PLOS ONE 9(4), e93401 (2014).

2013

Bases for Time-Resolved Probing of Transient Carrier Dynamics by Optical Pump-Probe Scanning Tunneling Microscopy,
M. Yokota, S. Yoshida, Y. Mera, O. Takeuchi, H. Oigawa, and H. Shigekawa,
Nanoscale, 2013, 5, 9170-9175 (2013).

2012

Frequency comb generation at THz frequencies by coherent phonon excitation in Si,
M. Hase, M. Katsuragawa, A. M. Constantinescu, and H. Petek,
Nature Photonics, 6, 243–247 (2012).

Nanoscale probing of transient carrier dynamics modulated in GaAs-PIN junction by laser-combined scanning tunneling microscopy,
S. Yoshida, Y. Terada, R. Oshima, O. Takeuchi and H. Shigekawa,
Nanoscale 4 (3), 757-761 (2012).

Observation of Raman Optical Activity by Heterodyne-Detected Polarization-Resolved Coherent Anti-Stokes Raman Scattering,
K. Hiramatsu, M. Okuno, H. Kano, P. Leproux, V. Couderc, and H. Hamaguchi,
Physical Review Letters 109, 083901 (2012).

2011

Ultrafast optical manipulation of atomic arrangements in chalcogenide alloy memory materials,
K. Makino, J. Tominaga, and M. Hase,
Optics Express, 19, 1260–1270 (2011).

Scanning tunneling microscopy/spectroscopy on self-assembly of glycine/Cu(111) nano cavity array.
K. Kanazawa, A. Taninaka, H. Huang, M. Nishimura, S. Yoshida, O. Takeuchi, and H. Shigekawa,
Chem. Commun., 47 (40), 11312-11314 (2011).

2010

Real space imaging of transient carrier dynamics by nanoscale pump-probe microscopy
Y. Terada, S. Yoshida, O. Takeuchi, and H. Shigekawa,
Nature Photonics, 4, 12, 869-874 (2010).

特許

観察システム、観察方法
発明者:重川秀実、谷中淳
出願番号 :特願2019-085774号 (出願日 2019.4.26)
国際出願番号 :第PCT/JP2020/017681号 (出願日 2020.4.24)
分光観察システム、観察方法
発明者:重川秀実、嵐田雄介
出願番号 :特願2020-100165号 (出願日 2020.6.9)
癌の罹患可能性の試験方法、癌の罹患可能性の判定装置、癌の罹患可能性の判定方法、癌の罹患可能性の判定に用いる学習済モデルの製造装置、癌の罹患可能性の判定に用いる学習済モデルの製造方法、および癌の罹患可能性の判定システム
発明者:加納英明・野口雅之・加野准子・湯口周・松井裕史・黒川宏美・岡祐・松本潤一(片岡製作所・筑波大学)
出願番号 :特願2019-201847号(出願日2019.11.6)
被験物質への感受性の判定方法、被験物質への感受性の判定装置、抗癌剤のスクリーニング方法、抗癌剤の候補物質の製造方法、学習済モデルの製造方法、学習済モデルの製造装置、および選抜方法
発明者:加納英明、松阪諭、岩村拓海、沈之為、松本潤一(片岡製作所・筑波大学)
出願番号 :特願2019-021932号(出願日 2019.2.8)
細胞種の推定方法、細胞種の推定装置、細胞の製造方法、細胞の製造装置、観察方法、観察装置、学習済モデルの製造方法、および学習済モデルの製造装置
発明者: 加納英明・林洋平・松本潤一(片岡製作所・筑波大学・理研)
出願番号 :特願2019-022032(出願日2019.2.8)
光出力システム、測定システム、光学的ポンプ・プローブ走査トンネル顕微鏡システム、演算器、プログラム
発明者:重川秀実、武内修、汪子涵
出願番号 :特願2018-233878号 (出願日 2018.12.13)
測定装置、近接場の測定方法
発明者:重川秀実、吉田昭二
出願番号 :特願2018-153746号 (出願日 2018.8.17)
医療用タンパク質とポリアミノ酸とを含む複合体の製造方法および医療用タンパク質とポリアミノ酸とを含む複合体
発明者:三村真大、白木賢太郎、飯渕るり子、赤塚直喜
特許出願番号: PCT/JP2018/027771(出願日 2018.7.24)
走査プローブ顕微鏡
発明者:重川秀実
出願番号 :特願2018-007557 号 (出願日 2018.1.19)
超解像顕微鏡
発明者:池滝慶記、加納英明
特許出願番号 2017-009290(出願日 2017.1.23)
超解像顕微鏡
発明者:池滝慶記、加納英明
特許出願番号 2016-251895(出願日 2016.12.26)
高濃度γグロブリン製剤の粘度低下方法
発明者:井上直人、高井英輔、白木賢太郎
特許公開番号:2013-143333(出願日 2013.7.9)
特許第6179939号
ポンププローブ測定装置
発明者:重川秀実、武内修
2011-169682(出願日 2011.8.2)
国際出願番号:第PCT/JP2012/069517号 (出願日 2012.7.31)
公開番号:2013-32993号(公開日 2013.2.14)
相変化記録膜を有する相変化装置、及び相変化記録膜の相変化スイッチング方法
発明者:長谷宗明、牧野孝太郎、富永淳二
国際公開番号:WO2011/052279(国際出願日 2010. 8. 9)
特許第5641485号(US Patent NO. 9029068B2)
ヘテロダインビートブローブ走査ブローブ顕微鏡
発明者:松山 英治、重川秀実、根本 承次郎、中村 潤児、大井川 治宏、武内修、保田 諭
国際公開番号:2006-000007号(出願日 2007.3.5)
ポンププローブ測定装置及びそれを用いた走査プローブ顕微鏡装置
発明者:重川秀実、武内修
国際公開番号:2006-322662号(出願日 2006.11.29)
国際出願番号:第PCT/JP2007/072988号(出願日 2007.11.28)
シリコン結晶析出方法及びシリコン結晶材料
発明者:村上浩一、内田紀行、深田直樹、北島正弘、長谷宗明
特許公開番号:2007−204353
特許出願番号:2006−29005(出願日 2006. 2. 26)
ガラス材料中に誘起された構造変化のその場診断法
発明者:北島正弘、長谷宗明、深田直樹、村上浩一、山本良明、荒井隆道
特許公開番号:2005−127924(出願日 2003.10. 24)
特許第3777425号
固体中の欠陥測定方法および欠陥測定装置
発明者:長谷宗明、北島正弘、石岡邦江、神成文彦、藤井康隆
特許公開番号:2004−349582(出願日 2003. 5. 23日)
特許第3830461号
遅延時間変調型フェムト秒時間分解走査プローブ顕微鏡装置
発明者:重川秀実、武内修、山下幹雄、森田隆二
国際公開番号:WO2003/046519(出願日 2001.11.26、国際出願日 2002.11.25)
EPO特許番号:第1460410号

受賞

令和元年度
BEST FACULTY MEMBER
走査トンネル顕微鏡法を基板とした極限計測技術の開拓
重川秀実
2019年度
日本表面真空学会講演奨励賞 新進研究者部門
光励起多探針計測を用いた単層WSe2/MoSe2面内ヘテロ構造の光応答評価
茂木裕幸, 汪子涵, 番場隆文, 髙口裕平, 遠藤尚彦, 吉田昭二, 谷中淳, 大井川治宏, 宮田耕充, 重川秀実
令和1年度
Free Radical Summer School 2019 日本酸化ストレス学会 学生ポスター最優秀賞
原子間力顕微鏡を用いた酸化ストレスによるガン細胞弾性率変化の観察
宇賀神 駿太
令和元年春
紫綬褒章
応用物理学研究分野
重川秀実
平成30年度
2018 International Conference on Nanoscience + Technology (ICN+T 2018) Best Poster Award of BLUE POSTER SESSION
Surface-mediated Electron Spin Dynamics of Mn Deposited GaAs[110] Probed by Optical Pump-probe scanning Tunneling Microscopy
Z. H. Wang, C.H .Yoon, S. Yoshida, O. Takeuchi and H. Shigekawa
平成27年度
科学技術分野の文部科学大臣表彰「科学技術賞」
フェムト秒時間分解トンネル顕微鏡の開拓と応用に関する研究
重川秀実
第37回(2015年度)
応用物理学会論文賞
Single-Atomic-Level Probe of Transient Carrier Dynamics by Laser-Combined Scanning Tunneling Microscopy
吉田昭二、横田統徳、武内修、大井川治宏、目良裕、重川秀実
平成26年度
島津賞
光励起フェムト秒時間分解走査トンネル顕微鏡技術の開拓
重川秀実
平成22年度
第15回日本表面科学会学会賞
走査プローブ顕微鏡と量子光学を融合した極限計測技術の開発
重川秀実
第2回(2008年)
日本物理学会若手奨励賞(領域5)
コヒーレントフォノン分光による半金属・半導体の電子・格子ダイナミクスの研究
長谷宗明
平成21年度
科学技術分野の文部科学大臣表彰「若手科学者賞」
超高速時間領域分光法の開発と格子ダイナミクス計測の研究
長谷宗明
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